Lymphoseek (technetium Tc 99m tilmanocept) Injection, a radioactive imaging agent that assists doctors in locating lymph nodes in breast cancer or melanoma patients who are having tumor-draining lymph nodes removed, has been approved by the US FDA (Food and Drug Administration). Lymphatic fluid flows from the body's tissues and is filtered by the lymph nodes...
The tops and bottoms of cells do different jobs, and healthy organs and tissue contain well-organized cells that are the right way up. One of the first signs of cancer is when cells become disorganized and can end up upside down. Now researchers in the UK have discovered how cells know when they are the right way up, and suggest this knowledge will help in the fight against cancer...
Mutations in a gene known as PPM1D are associated with a higher risk of breast and ovarian cancer - which may represent a new cancer-causing process. The finding came from a new study published in the journal Nature which was conducted by a team of experts from The Institute of Cancer Research, London...
New understanding of how drugs called PARP inhibitors, which have already shown promise for the treatment of women with familial breast and ovarian cancers linked to BRCA mutations, exert their anticancer effects has led to the identification of ways in which the patient population that might benefit from PARP inhibitors could be expanded. Yves Pommier, M.D., Ph.D...
Cancer metastasis, the escape and spread of primary tumor cells, is a common cause of cancer-related deaths. But metastasis remains poorly understood. Studies indicate that when a primary tumor breaks through a blood vessel wall, blood's "stickiness" tears off tumor cells the way a piece of tape tears wrapping paper...
Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, the misfolding nature of prions is associated to their ability to sequester their normal counterparts and induce them to also adopt a misfolding conformation...
Once considered merely a passive link between proteins that matter, Grb2 - pronounced "grab2" - actually lives up to its nickname with its controlling grip on an important cell signaling pathway, scientists at The University of Texas MD Anderson Cancer Center report in Cell...
Chromosomal deletions in DNA often involve just one of two gene copies inherited from either parent. But scientists haven't known how a deletion in one gene from one parent, called a "hemizygous" deletion, can contribute to cancer...
A team of scientists from the National University of Singapore's (NUS) Department of Biological Sciences and Mechanobiology Institute have discovered how a drug-lead compound - a compound that is undergoing preclinical trials as a potential drug - can deprive cancer cells of energy and stop them from growing into a tumour. This drug-lead compound is named BPTES...
New research showing that almost half of 13,000 patients with head and neck cancers had other health-related problems at the same time was one of the presentations in a special session at the 31st conference of the European Society for Radiotherapy and Oncology (ESTRO 31) [1]. The session highlighted the effect of the demographic time bomb caused by an increasingly ageing population...
